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The Polymeric Biomaterials and Tissue Engineering Lab is part of the department of Biomedical Engineering (BME) at the Illinois Institute of Technology (IIT). Our research is aimed at designing polymeric multifunctional biomaterials with particular emphasis on crosslinked hydrogels for applications in tissue engineering and drug delivery.  Research in tissue engineering focuses on the development of novel polymerization approaches used to design hydrogel scaffolds that contain spatial and temporal biological signals, mechanical properties and physical structure to guide cell behavior and tissue regeneration.  We are also developing hydrogel nanoparticle carriers with tunable release kinetics for sustained delivery of angiogenic signals, therapeutic drugs and small molecules.  Our research in biomaterials is highly interdisciplinary in that it combines experimental and computational approaches to gain fundamental understanding of the kinetics of gelation required for optimization of hydrogel properties and structure-function relationships. Our goal is to combine in silico, in vitro, and in vivo methodologies in order to tailor and optimize biomaterials to address issues of  clinical significance.

News

Wesley Lo receives the following awards for undergraduate research in spring 2016: 1). High Score and Overall High Score awards at the 2nd Annual Armour R&D Expo, 2). Top Presenter from Illinois Tech at the Chicago Area Undergraduate Research Symposium (CAURS), 3). Undergraduate Winner at the 2016 IIT Research Day.

 

Georgia Papavasiliou awarded an American Heart Association NCRP Summer Innovation Research Grant-January 2016

 

Georgia Papavasiliou awarded an NIH R21 grant from the National Institute of Allergy and Infectious Disease-April 2016

 

Georgia Papavasiliou selected among 250 participants to attend the first AHA/ASA Research Leaders Academy in San Antonio, Texas- July 24-26, 2016.

Recent Publications

Yushu Yin, Georgia Papavasiliou, Olga Zaborina, John Alverdy, Fouad Teymour. De Novo Synthesis and Functional Analysis of Polyphosphate-Loaded Poly(ethylene) Glycol Hydrogel Nanoparticles Targeting Pyocyanin and Pyoverdin Production in Pseudomonas aeruginosa as a Model Intestinal Pathogen. Annals of Biomedical Engineering (Accepted)

 

Vaicik MK, Morse M, Blagajcevic A, Rios J, Larson JC, Yang F, Cohen RN, Papavasiliou G, Brey EM. Hydrogel-based engineering of beige adipose tissue. Journal of Materials Chemistry B. 3(40):7903-7911, 2015.

 

Sokic S, Appel A, Larson J, Christenson M, Brey E, and Papavasiliou G*. Evaluation of MMP Substrate Specificity and Concentration for Neovascularization of Hydrogel Scaffolds. Biomaterials Science. 2(10): 1343-1354, 2014. (Featured In Cover)

 

For further information about research opportunities please contact papavasiliou@iit.edu